After some very thorough testing, and determining that it is safe, I have decided to share the following:

http://www.mediafire.com/download/py59ycs271jq5qq/hosts.zip
This contains a massive list of malicious websites, and advertisement servers.
When installed, your computer will block all of the items in the list.

After some thorough testing, the end results have more than proven themselves, with the big feature being that ads are gone in a number of programs and websites.

Just to name a few:
Skype
Aim
Youtube (The exception of broken segments loaded via script)
Hulu (Though it forces a waiting period, [which is still shorter than it's ads])


How to install:
Windows XP and below should not have any problems running the included .BAT file within the .zip

Windows Vista and above:
Right click on "mvps.bat" and click "Run as administrator" then follow the on-screen instructions.
This will back up the current existing hosts file, and insert the contents of the one within the .zip.

It might not be a complete replacement for Adblock, but as a first line of defense, it is well worth it.

With that said: enjoy.

This sounds quite useful indeed. Not only does it remove annoying ads, it helps protect your PC from malicious Web sites. I'm personally OK with relying on AdBlock, but I might try this if the Skype ads get too bothersome.

I feel the incredible need to state that I feel that it's better to be preventive rather than reactive when it comes to something like this!

There was a time where an ad in a Skype rotation was a malicious one that automatically opened the default browser to the site of a fake anti-virus. It can be assumed that this could still happen again as a result of higher-up negligence, and that the end site could host drive-by downloads. Do you really trust Microsoft enough to not let that happen again? Granted, that is a worst case scenario of questionable likelihood, but this is a case where I feel that line of thinking is acceptable.

I do believe in there being "good" or "acceptable" ads, but I personally don't trust any providers anywhere ever to keep them safe.
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Edited by: Miles, Jan 5th, 2016 @ 11:02 am

Miles: That is a very, very, very good point.

Good gosh. Perhaps "questionable likelihood" was incorrect, as were my thoughts behind the "let it happen" bit. I didn't really consider the scale of everything. That's messed up.
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Edited by: Miles, Jan 12th, 2016 @ 2:27 pm